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PDE inhibitors for the treatment of erectile dysfunction. WHY??
Erectile dysfunction (ED) is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity. In order to understand why PDE inhibitors are used to treat ED, it is important to first understand what causes ED.
There are two main types of ED, psychogenic and organic. Psychogenic ED is caused by psychological factors such as stress, anxiety, or depression. Organic ED is caused by physical factors such as diabetes, high blood pressure, or other medical conditions.
PDE inhibitors are used to treat ED because they improve blood flow to the penis. PDE inhibitors work by blocking the enzyme phosphodiesterase, which breaks down a substance called cGMP. cGMP is responsible for relaxing the smooth muscle cells in the penis, which allows for increased blood flow.
There are several different PDE inhibitors that are used to treat ED, including sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). These medications are taken orally, typically 30-60 minutes before sexual activity.
PDE inhibitors are generally well-tolerated, with the most common side effects being headache, flushing, and upset stomach. These medications are not right for everyone, so it is important to talk to your doctor about whether or not they are a good option for you.