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What is POST-SSRI SEXUAL DYSFUNCTION| PSSD | Antidepressants and Persistent Sexual Dysfunction? Read about it and find out how to solve the problem.

What is POST-SSRI SEXUAL DYSFUNCTION| PSSD | Antidepressants and Persistent Sexual Dysfunction

Post-SSRI sexual dysfunction (PSSD) is a condition in which sexual side effects of antidepressant medication do not go away after the person stops taking the medication. PSSD can cause a range of symptoms, including loss of libido, difficulty achieving orgasm, and erectile dysfunction.

The exact cause of PSSD is unknown, but it is thought to be caused by changes in the level of serotonin, a brain chemical that plays a role in sexual function. PSSD is more common in women than men, and it can occur after taking any type of antidepressant, although selective serotonin reuptake inhibitors (SSRIs) seem to be the most likely to cause the condition.

There is no cure for PSSD, but there are treatments that can help lessen the symptoms. These include therapy, medication, and lifestyle changes.

Symptoms

The symptoms of PSSD can vary from person to person. They may include:

  • Loss of libido – a decreased interest in sex
  • Difficulty achieving orgasm – either unable to reach orgasm or takes much longer than usual
  • Erectile dysfunction – either unable to get or maintain an erection
  • Vaginal dryness – a decrease in vaginal lubrication
  • Pain during sex – either due to vaginal dryness or because of anorgasmia (difficulty reaching orgasm)
  • Anxiety – about sexual performance or about the changes in sexual function

PSSD can also cause other symptoms not related to sexual function, such as fatigue, brain fog, and depression.

Causes

The exact cause of PSSD is unknown. However, it is thought to be caused by changes in the level of serotonin, a brain chemical that plays a role in sexual function.

PSSD is more common in women than men, and it can occur after taking any type of antidepressant, although SSRIs seem to be the most likely to cause the condition.

Treatments

There is no cure for PSSD, but there are treatments that can help lessen the symptoms. These include therapy, medication, and lifestyle changes.

Therapy can help people with PSSD deal with the emotional effects of the condition. A therapist can also teach coping and problem-solving skills.

Medication can be used to treat some of the symptoms of PSSD, such as anxiety, depression, and pain. However, there is no medication that is specifically approved for the treatment of PSSD.

Lifestyle changes can also help people with PSSD. These may include exercise, relaxation techniques, and changes in diet.

Dr Sanil Rege, Consultant Psychiatrist explains Post-SSRI Sexual Dysfunction (PSSD).

PSSD is a condition that arises after the use of SSRIs, in which patients continue to have sexual side effects after the discontinuation of SSRIs.

#postssrisexualdysfunction #pssd #antidepressants

Intro to PSSD: 00:00

Clinical Features of PSSD: 01:17

02:35 – Medications associated with PSSD

04:29 – Causes of Post -SSRI Sexual Dysfunction (PSSD)

08:07 – Diagnosing Post -SSRI Sexual Dysfunction (PSSD)

08:48 – Treatment of Post -SSRI Sexual Dysfunction (PSSD)

The prevalence of persistent sexual side effects after discontinuing SSRIs is not well known.

Common symptoms of PSSD are :

1.Genital Anaesthesia

2. Decreased libido

3. Erectile dysfunction

4. Pleasure-less or weak orgasm

5. Premature ejaculation

6. Vaginal lubrication problems

7. Nipple insensitivity

There are two types of PSSD:

1. Sexual dysfunction occurring while SSRIs are being used and persisting after discontinuing treatments

2. After the discontinuation of SSRIs as an aggravation of SSRI-induced sexual side effects.

Causes:

The exact causes are not known. some postulated mechanisms are:

1. 5HT1A persistent downregulation

2. Dopaminergic system involvement

3. HPA axis and Hormone involvement

4. Effect on Transient receptor potentials via ion channels

5. Decreased nitric oxide synthesis (NO)

6. Axonal damage (Neurotoxicity)

Diagnosis:

Challenging

Other medical conditions and psychiatric disorders should be ruled out.

Treatment:

1. Monitoring and prevention are important

2. Consider agents such as Agomelatine, Vortioxetine, Bupropion, Moclobemide, and Mirtazapine with a lower incidence of sexual side effects youtu.be/b71OzPujQDg

3. Phototherapy (case report)

4. Switch to amineptine

5. Switch to bupropion

6. Complementary therapies (insufficient evidence)

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Video transcription:

What users commented:

I have to say id heard about this before and it was the main reason i dont want to take them i dont like the thought that they are taking away my sex drive pretty much i just cant see that id be less depressed at that point

Has anybody cured from this? I’ve hardly seen any cases of people recovering from this, including on the reddit forum

Thank you for posting this video! This condition really needs to be researched into so treatment can be developed!

Is it true that they prescribe these drugs as treatment for paraphilic sexual behavior?

Gracias por hablar sobre pssd tenía 18 años cuando esto destruyo mi vida acá en México es menos hablado sobre esto

Funny how we don’t know the treatment but create the drug that is responsible and have knowledge of the mechanism of action, how dopamine and norepinephrine etc ., are affected. I might be worried for nothing but I find that very unethical and appalling.

Thank you for ur supoort to show the world about this issues

I have PSSD after Brintellix. Should I still consider Bupropion?

I didn’t spell trials in the comments I made thank you for responding Doctor!let me also share some sudjestion for my fellows(vets)that have expressed these symptoms!Please consult your physician before you attempt these sudjestions!for my pain(CBD )oils I choose organic pure oils as an alternative and have found help for erectile dysfunctional conditions so fare the Wholelistic way !I’ll share those for you at latter time if you will thanks agin Doc!

Having you as my doctor is also a positivity that I don’t really have to bother about any sickness or virus,because your herbal medication of erectile dysfunction has shown not only me but the world how good your products are and I’ll keep recommending you..

CURE PLEASE

I wish this issue gained more strength here in Brazil, many people are going through this here, but most psychiatrists are unaware of the PSSD.

I’ve seen success stories of people who used antidepressants saying their sex drive actually improved on SSRI (Lexapro), honestly after seeing these reviews all the time I’m thinking that PSSD is very rare , i wish it was known how rare it is tho…

Carefully I look see and understanding I have the ability to archive more than I imagined thanks to Dr osaye, I was able to get rid of my erectile dysfunction which I thought was permanent was not,just after taking his medication I could firmly control my erections..

CRIMINALI

Is it possible that tretinoin that is prescribed by dermatologists can cause PSSD ? It’s not a pill, you apply it on your face basically, isotretinoin causes PSSD so that’s why I’m worried about using it on my face

Please could you kindly discuss a video talk on Emetephobia? (Fear of V0miting) I would be especially keen to look at it all from a psychiatrist perspective

We have a group of more than 170 people from all around the world having post finasteride syndrome. (Finasteride/dutesteride for hair loss/alopecia)The side effects are also almost same as pssd, loss of lobido, no sexual desire, depression, brain fog, i am also victim. Ruined our life. Dr. Melcangi is doing research but only for pfs.

Thank you soooo much for addressing this topic. All of the doctors we have been to know nothing about this. Thanks especially for addressing possible treatments. Now if we can only find a doctor that will address the issues.