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Erectile dysfunction drugs may increase the effects of chemotherapy in esophagus cancer
Erectile dysfunction (ED) drugs may help increase the effects of chemotherapy in patients with esophageal cancer, according to a new study.
The study, published in the journal Cancer, found that the ED drug sildenafil (Viagra) may help increase the sensitivity of esophageal cancer cells to chemotherapy.
In the study, researchers treated esophageal cancer cells with sildenafil and then exposed them to the chemotherapy drug cisplatin.
They found that sildenafil increased the sensitivity of the cancer cells to cisplatin by up to five times.
The researchers say that the findings suggest that sildenafil may be a useful adjunct to chemotherapy in the treatment of esophageal cancer.
This is the first study to show that sildenafil can increase the sensitivity of cancer cells to chemotherapy, said study author Dr. Ravi Salgia, of the University of Chicago. This finding opens up the possibility that sildenafil could be used in combination with chemotherapy to treat esophageal cancer.
Salgia and colleagues are now planning a clinical trial to test the efficacy of sildenafil in combination with chemotherapy in patients with esophageal cancer.